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No tirzepatide is contraindicated in individuals with personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

The fatty acid composition of sperm cell membranes has long been recognized as a factor in sperm function, and DHA in particular appears to be preferentially concentrated in sperm membranes

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AOD9604 stimulates collagen type II and aggrecan synthesis in chondrocytes

In such cases, NICE and BNF guidance supports co-prescribing a proton pump inhibitor (PPI) such as omeprazole or lansoprazole to reduce gastric acid and protect the mucosal lining